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| Item 8.01. | Other Events. |
On August 15, 2022, Anixa Biosciences, Inc. (the “Company”) announced that, in conjunction with the Company’s partner Moffitt Cancer Center, the Company has commenced treatment of the first patient in the clinical trial of the Company’s novel chimeric antigen receptor T-cell (CAR-T) therapy for ovarian cancer. The study is a dose-escalation Phase 1 trial to determine safety and the maximum tolerated dose of follicle stimulating hormone receptor T-cells and to preliminarily assess efficacy. The study is being conducted at Moffitt Cancer Center and may consist of up to 48 patients. The CAR-T approach used for the Company’s therapy is known as chimeric endocrine receptor T-cell (CER-T) since the target of the engineered T-cells is an endocrine receptor. While CAR-T therapy has shown efficacy in some hematological tumors, reproducing the same results with solid tumors, such as ovarian cancer, has proven challenging. We believe one of the reasons for this difficulty is that effective CAR-T therapy needs a specific antigen to recognize that is only present on target cancer cells in order to avoid negatively affecting healthy cells. The CER-T therapy being evaluated in the Company’s Phase 1 study differs from traditional CAR-T in that it targets the follicle stimulating hormone receptor (FSHR), which research indicates may be exclusively expressed on ovarian cells in healthy adult females.
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.
Dated: August 17, 2022
| ANIXA BIOSCIENCES, INC. | ||
| By: | /s/ Amit Kumar | |
| Name: | Dr. Amit Kumar | |
| Title: | Chief Executive Officer | |